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Epigenetic modification is linked to Alzheimer's disease: is it a maker or a marker?

BMB reports - 1 Oct 2010

Lee Junghee, Ryu Hoon

Abstract excerpt

Alzheimer's disease (AD) is the most common age-dependent neurodegenerative disorder and shows progressive memory loss and cognitive decline. Intraneuronal filaments composed of aggregated hyperphosphorylated tau protein, called neurofibrillary tangles, along with extracellular accumulations of amyloid ß protein (Aß), called senile plaques, are known to be the neuropathological hallmarks of AD. In light of recent...

Topics

Alzheimer Disease
Animals
Biomarkers
Chromatin Assembly and Disassembly
Epigenesis, Genetic
Genetic Predisposition to Disease
Humans
Models, Biological
Sirtuins

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 21034526
DOI: 10.5483/BMBRep.2010.43.10.649

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APP

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