Back to search

Article

The chromatin conformation landscape of Alzheimer’s disease

2024-04-13

Abstract excerpt

<h4>ABSTRACT</h4> We have been investigating epigenetic alterations in the brain during human aging and Alzheimer’s disease (AD), and have evidence for histone acetylation both protecting the aging epigenome and driving AD. Here we extend our studies to chromatin architecture via looping studies, and with binding studies of key proteins required for looping: CTCF and RAD21. We detected changes in CTCF and RAD21 l...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
f38dcd53-dd15-5108-bdbb-c1e6ed987392
DOI
10.1101/2024.04.09.588722
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
The chromatin conformation landscape of Alzheimer’s diseaseDOI 10.1101/2024.04.09.588722
Epigenome-wide study uncovers tau pathology-driven changes of chromatin organization in the aging human brainSemantic proximity
Interplay Between 3D Chromatin Architecture and Gene Regulation at the APOE Locus Contributes to Alzheimer's Disease Risk.Semantic proximity
Brain Region-Specific Epigenomic Reorganization and Altered Cell States in Alzheimer’s DiseaseSemantic proximity
Epigenome erosion in Alzheimer’s disease brain cells and induced neuronsSemantic proximity
Epigenome-wide study uncovers large-scale changes in histone acetylation driven by tau pathology in aging and Alzheimer’s human brainsSemantic proximity
Mapping enhancer and chromatin accessibility landscapes charts the regulatory network of Alzheimer's diseaseSemantic proximity
The three-dimensional landscape of chromatin accessibility in Alzheimer’s diseaseSemantic proximity
Finding ancestry-specific chromatin architecture in Alzheimer’s diseaseSemantic proximity
The Divergent 3D Genome Landscapes of Aging and Neurodegenerative mouse modelsSemantic proximity
Deciphering aging at three-dimensional genomic resolutionSemantic proximity
Enhancer variants associated with Alzheimer’s disease affect gene expression via chromatin loopingSemantic proximity
Opposing effects of histone H2A.Z on memory, transcription and pathology in male and female Alzheimer’s disease mice and patientsSemantic proximity
Select a neighboring publication to make it the new centre.