Article

On the transient interactions of α-synuclein in different dimensions

2025-01-31

Abstract excerpt

0. α-Synuclein (αSyn) is a neuronal protein predominantly found in the brain, whose native function seems to be associated with vesicle trafficking. While intrinsically disordered in solution, the first ca. 100 residues adopt an amphipathic α-helical structure when the protein adsorbs onto membranes. Additionally, the aggregation of αSyn into highly ordered β-sheet rich amyloid fibrils is associated with Parkinsoń...

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Literature Corpus work: 8b62c6d6-37f4-5bc6-9dd2-385173ddaa5f
DOI: 10.1101/2025.01.29.635265

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