Article

Selectivity of Protein Interactions along the Aggregation Pathway of α-Synuclein

2021-01-29

Abstract excerpt

The aggregation of α-SYN follows a cascade of oligomeric, prefibrillar and fibrillar forms, culminating in the formation of Lewy Bodies (LB), the pathological hallmarks of Parkinson’s Disease in neurons. Whilst α-synuclein is a major contributor to LB, these dense accumulations of protein aggregates and tangles of fibrils contain over 70 different proteins. However, the potential for interactions between these pro...

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Literature Corpus work: 9d1fc5c0-0a98-55fa-82a7-79d3120491ac
DOI: 10.1101/2021.01.29.428744

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