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Article

Conformational equilibria in monomeric alpha-synuclein at the single-molecule level.

PLoS biology - 1 Jan 2008

Sandal Massimo, Valle Francesco, Tessari Isabella, Mammi Stefano, Bergantino Elisabetta, Musiani Francesco, Brucale Marco, Bubacco Luigi, Samorì Bruno

Abstract excerpt

Human alpha-Synuclein (alphaSyn) is a natively unfolded protein whose aggregation into amyloid fibrils is involved in the pathology of Parkinson disease. A full comprehension of the structure and dynamics of early intermediates leading to the aggregated states is an unsolved problem of essential importance to researchers attempting to decipher the molecular mechanisms of alphaSyn aggregation and formation of...

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PMID: 18198943
DOI: 10.1371/journal.pbio.0060006
PMCID: PMC2174973

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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