Article

The structural heterogeneity of α-synuclein is governed by several distinct subpopulations with interconversion times slower than milliseconds

2020-11-09

Abstract excerpt

The intrinsically disordered protein, α-synuclein, implicated in synaptic vesicle homeostasis and neurotransmitter release, is also associated with several neurodegenerative diseases. The different roles of α-synuclein are characterized by distinct structural states (membrane-bound, dimer, tetramer, oligomer, and fibril), which are originated from its various monomeric conformations. The pathological states, deter...

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Literature Corpus work: 87aa24c8-5b3a-517d-9033-2d4cdcade3e0
DOI: 10.1101/2020.11.09.374991

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