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The C-terminus of α-Synuclein Regulates its Dynamic Cellular Internalization by Neurexin 1β

20 Sept 2023

Abstract excerpt

The aggregation of the disordered neuronal protein, α-Synuclein (αS), is the primary pathological feature of Parkinson's disease. Current hypotheses favor cell-to-cell spread of αS species as underlying disease progression, driving interest in identifying the molecular species and cellular processes involved in cellular internalization of αS. Prior work from our lab identified the chemically specific interaction...

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PMID: 37729016
DOI: 10.1091/mbc.e22-11-0496

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