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Article

Self-limiting multimerization of α-synuclein on membrane and its implication in Parkinson's diseases.

Science advances - 11 Oct 2024

Ma Dong-Fei, Zhang Shenqing, Xu Si-Yao, Huang Zi, Tao Yuanxiao, Chen Feiyang, Zhang Shengnan, Li Dan, Chen Tongsheng, Liu Cong, Li Ming, Lu Ying

Abstract excerpt

α-Synuclein (α-syn), a crucial molecule in Parkinson's disease (PD), is known for its interaction with lipid membranes, which facilitates vesicle trafficking and modulates its pathological aggregation. Deciphering the complexity of the membrane-binding behavior of α-syn is crucial to understand its functions and the pathology of PD. Here, we used single-molecule imaging to show that α-syn forms multimers on lipid...

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Identifiers

PMID: 39383232
DOI: 10.1126/sciadv.ado4893
PMCID: PMC11463274

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