Article

Reconstitution of Helical Soluble α-Synuclein through Transient Interaction with Lipid Interfaces

2017-10-13

Abstract excerpt

α-synuclein (αSyn) is one of the key players in the pathogenesis of Parkinson’s disease (PD) and other synucleinopathies. Its misfolding and subsequent aggregation into intracellular inclusions are the pathological hallmark of these diseases and may also play a central role in the molecular cascade leading to neurodegeneration. In this work, we report the existence of a novel soluble α-helical conformer of αSyn, a...

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Literature Corpus work: b8bf165e-5466-5010-a474-9f31a6f7ba96
DOI: 10.1101/202994

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