Article
Oligomers of α-synuclein: picking the culprit in the line-up.
Essays in biochemistry - 1 Jan 2014
Lorenzen Nikolai, Otzen Daniel E
Abstract excerpt
In the present chapter, we discuss the key findings on αsyn (α-synuclein) oligomers from a biophysical point of view. Current structural methods cannot provide a high-resolution structure of αsyn oligomers due to their size, heterogeneity and tendency to aggregate. However, a low-resolution structure of a stable αsyn oligomer population is emerging based on compelling data from different research groups. αsyn...
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