Article

Asymmetric Boost Responses to an HIV-1 Vaccine: Boost-site Controls Secondary B-cell Fates

2026-08-17

Abstract excerpt

Induction of broadly neutralizing antibody (bnAb) responses remains a central challenge to designing efficacious HIV vaccines. Lineage design strategies, in which bnAb precursors are guided via iterative immunizations to their mature forms, depend on high levels of somatic mutation and the recall of antigen-specific B cells. Recent studies have identified spatial context as an important determinant of boosting ef...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 2a9d198d-165e-516d-9d31-29a17e190e12
DOI: 10.64898/2026.08.11.744292

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Asymmetric Boost Responses to an HIV-1 Vaccine: Boost-site Controls Secondary B-cell FatesDOI 10.64898/2026.08.11.744292Read

Antigen affinity and site of immunization dictate B cell recall responsesSemantic proximity Read

Multiple broadly neutralizing antibody lineages can co-exist and mature in the same germinal centresSemantic proximity Read

Tailored Immunogens Direct Affinity Maturation toward HIV Neutralizing Antibodies.Semantic proximity Read

Restricted Clonality and Limited Germinal Center Reentry Characterize Memory B Cell Reactivation by BoostingSemantic proximity Read

Anti-HIV-1 B cell responses are dependent on B cell precursor frequency and antigen binding affinitySemantic proximity Read

Engineered B cells expressing an anti-HIV antibody enable memory retention, isotype switching and clonal expansion.Semantic proximity Read

Antibody Affinity Shapes the Choice between Memory and Germinal Center B Cell Fates.Semantic proximity Read

Long-lasting germinal center responses to a priming immunization with continuous proliferation and somatic mutationSemantic proximity Read

Diverse priming outcomes under conditions of very rare precursor B cellsSemantic proximity Read

Binding dynamics shape germinal center broadly neutralizing responses to HIV primingSemantic proximity Read

Binding dynamics shape germinal center broadly neutralizing responses to HIV primingSemantic proximity Read

Rapid acquisition of HIV-1 neutralization breadth in a rhesus V2 apex germline antibody mouse model after a single bolus immunizationSemantic proximity Read