Mutation-guided vaccine design: A process for developing boosting immunogens for HIV broadly neutralizing antibody induction.

doi:10.1016/j.chom.2024.04.006

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Article

Mutation-guided vaccine design: A process for developing boosting immunogens for HIV broadly neutralizing antibody induction.

Cell host & microbe - 8 May 2024

Wiehe Kevin, Saunders Kevin O, Stalls Victoria, Cain Derek W, Venkatayogi Sravani, Martin Beem Joshua S, Berry Madison, Evangelous Tyler, Henderson Rory, Hora Bhavna, Xia Shi-Mao, Jiang Chuancang, Newman Amanda, Bowman Cindy, Lu Xiaozhi, Bryan Mary E, Bal Joena, Sanzone Aja, Chen Haiyan, Eaton Amanda, Tomai Mark A, Fox Christopher B, Tam Ying K, Barbosa Christopher, Bonsignori Mattia, Muramatsu Hiromi, Alam S Munir, Montefiori David C, Williams Wilton B, Pardi Norbert, Tian Ming, Weissman Drew, Alt Frederick W, Acharya Priyamvada, Haynes Barton F

Abstract excerpt

A major goal of HIV-1 vaccine development is the induction of broadly neutralizing antibodies (bnAbs). Although success has been achieved in initiating bnAb B cell lineages, design of boosting immunogens that select for bnAb B cell receptors with improbable mutations required for bnAb affinity maturation remains difficult. Here, we demonstrate a process for designing boosting immunogens for a V3-glycan bnAb B...

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Identifiers

PMID: 38670093
DOI: 10.1016/j.chom.2024.04.006
PMCID: PMC13215451

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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