Article
Tailored Immunogens Direct Affinity Maturation toward HIV Neutralizing Antibodies.
Cell - 8 Sept 2016
Briney Bryan, Sok Devin, Jardine Joseph G, Kulp Daniel W, Skog Patrick, Menis Sergey, Jacak Ronald, Kalyuzhniy Oleksandr, de Val Natalia, Sesterhenn Fabian, Le Khoa M, Ramos Alejandra, Jones Meaghan, Saye-Francisco Karen L, Blane Tanya R, Spencer Skye, Georgeson Erik, Hu Xiaozhen, Ozorowski Gabriel, Adachi Yumiko, Kubitz Michael, Sarkar Anita, Wilson Ian A, Ward Andrew B, Nemazee David, Burton Dennis R, Schief William R
Abstract excerpt
Induction of broadly neutralizing antibodies (bnAbs) is a primary goal of HIV vaccine development. VRC01-class bnAbs are important vaccine leads because their precursor B cells targeted by an engineered priming immunogen are relatively common among humans. This priming immunogen has demonstrated the ability to initiate a bnAb response in animal models, but recall and maturation toward bnAb development has not...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.