Article

Transcriptional coregulation <i>in cis</i> around a contact insulation site revealed by single-molecule microscopy

2025-03-06

Abstract excerpt

Chromosome conformation in mammals is closely related to gene regulation. Within topologically associating domains, where genomic contacts are enriched, genes tend to show correlated expression across tissues and conditions, suggesting domain-wide mechanisms coregulating multiple genes, such as enhancer sharing or local histone mark spreading. At the single-cell level, where transcription occurs in sporadic bursts...

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Literature Corpus work: 8a33fcb0-5efe-5e42-b882-4e563c3870cf
DOI: 10.1101/2025.03.04.641491

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