Article

Transcription factor expression is the main determinant of variability in gene co-activity

2022-10-14

Abstract excerpt

Many genes are co-expressed and form genomic domains of coordinated gene activity. However, the regulatory determinants of domain co-activity remain unclear. Here, we leverage human individual variation in gene expression to characterize the co-regulatory processes underlying domain co-activity and systematically quantify their effect sizes. We employ transcriptional decomposition to extract from RNA expression da...

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Literature Corpus work: 34e74391-5178-548c-9d42-cd8a5b62ec31
DOI: 10.1101/2022.10.11.511770

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