Article

Regulatory roles of three-dimensional structures of chromatin domains

2022-07-23

Abstract excerpt

1 Transcriptional enhancers usually, but not always, regulate genes within the same topologically associating domain (TAD). We hypothesize that this incomplete insulation is due to three-dimensional structures of corresponding chromatin domains in individual cells: Whereas enhancers and genes buried inside the “core” of a domain interact mostly with other regions in the same domain, those on the “surface” can more...

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Literature Corpus work: c113ff50-4f1c-50c9-be99-a0d39c6ec2cd
DOI: 10.1101/2022.07.22.501196

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