Article

Shared regulation and functional relevance of local gene co-expression revealed by single cell analysis

2021-12-16

Abstract excerpt

Most human genes are co-expressed with a nearby gene. Yet, previous studies only reported this extensive local gene co-expression using bulk RNA-seq. Here, we leverage single cell datasets in >85 individuals to identify gene co-expression across cells, unbiased by cell type heterogeneity and benefiting from the co-occurrence of transcription events in single cells. We discover thousands of co-expressed genes in tw...

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Literature Corpus work: 1a5d9a63-c4c4-5e15-84a3-bd06b349c038
DOI: 10.1101/2021.12.14.472573

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