Article

Simultaneous quantification of protein-DNA contacts and transcriptomes in single cells

2019-01-24

Abstract excerpt

The epigenome plays a critical role in regulating gene expression in mammalian cells. However, understanding how cell-to-cell heterogeneity in the epigenome influences gene expression variability remains a major challenge. Here we report a novel method for simultaneous single-cell quantification of protein-DNA contacts with DamID and transcriptomics (scDamID&T ) . This method enables quantifying the impact of pro...

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Literature Corpus work: 5badf47e-3ffe-517e-bb3f-4cc7dd70f2ba
DOI: 10.1101/529388

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