Article

Allelic Transcription Factor binding shape transcriptional kinetics observed with scRNA-seq in human cell lines

2022-09-22

Abstract excerpt

Gene expression from bulk RNA-seq studies is an average measurement between two chromosomes and across cell populations. Both allelic and cell-to-cell heterogeneity in gene expression results from promoter bursting patterns that repeatedly alternate between an activated and inactivated state. Increased cell-to-cell heterogeneity in gene expression has been associated with aging and stem cell pluripotency. However,...

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Literature Corpus work: 56d22da5-95d9-575a-8fe4-021fe5d62b6a
DOI: 10.1101/2022.09.21.508743

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