Article

A feedback control for restraining autoimmune γδ T cells: reprogramming into ILC1s

2026-06-10

Abstract excerpt

<h4>Summary</h4> γδ T cells are promising mediators of cancer immunotherapy, yet their potential to drive autoimmunity remains incompletely understood. Here, we identify a feedback mechanism in which innate-like Vγ1.1⁺Vδ6.3⁺ T cells are reprogrammed into ILC1-like cells, thereby restraining autoimmune pathology. We define a previously unrecognized ILC1 subset whose development depends on an intact Tcrd locus. Th...

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Identifiers and source

Literature Corpus work: 8a189040-06b9-5d9f-9856-1183bfcd97f7
DOI: 10.64898/2026.06.05.730476

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