Article

Uncovering Immune Surveillance Deficiency in B Cell-Driven Autoimmune Disease

2025-01-15

Abstract excerpt

<title>Abstract</title> <p>Antiphospholipid syndrome (APS) serves as a prototypical disease model for investigating immune tolerance breakdown in systemic autoimmunity of B cell. Single-cell RNA and V(D)J repertoire sequencing on paired bone marrow and peripheral blood from untreated primary APS patients enabled an integral “central-to-periphery” B cell blueprint at single-cell resolution, wherein we observed a s...

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Literature Corpus work: 107ee129-948d-53e8-9896-a7795c5faef9
DOI: 10.21203/rs.3.rs-5762949/v1

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