Article

A Germinal Center Checkpoint of AIRE in B Cells Limits Antibody Diversification

2024-01-12

Abstract excerpt

<h4>SUMMARY</h4> In response to antigens, B cells undergo antibody diversification, including affinity maturation and class switching, mediated by activation-induced cytidine deaminase (AID) in secondary lymphoid organs, but uncontrolled AID activity can precipitate autoimmunity and cancer. The regulation of antibody diversification is of fundamental importance, though the mechanisms underlying these pathways are...

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Literature Corpus work: 3851dd49-71c5-545e-96a2-bdd9d0378e64
DOI: 10.1101/2024.01.10.574926

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