Article

Uncontrolled CD21 <sup>low</sup> age-associated and B1 B cell accumulation caused by failure of an EGR2/3 tolerance checkpoint

2021-07-02

Abstract excerpt

<h4>SUMMARY</h4> CD21 low age-associated or atypical memory B cells, enriched for autoantibodies and poised for plasma cell differentiation, accumulate in large numbers in chronic infections, autoimmune disease and immunodeficiency, posing the question of what checkpoints normally oppose their excessive accumulation. Here, we reveal a critical role for the calcium-NFAT-regulated transcription factors EGR2 and EG...

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Literature Corpus work: 26c5f6bc-f229-5d7d-9b55-5abecaeb1927
DOI: 10.1101/2021.07.01.450650

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