Article

<i>VCAM1</i>-expressing T cells and systemic autoimmunity in Regnase-1 deficiency

2025-01-22

Abstract excerpt

<h4>Summary</h4> Autoimmunity develops as a result of a breakdown in immune tolerance and activation of autoreactive immune cells. Most of the common autoimmune diseases are polygenic 1 suggesting dysregulation in multiple signalling pathways. By contrast, in monogenic Inborn Errors of Immunity (IEI), which also can result in autoimmunity, the disease is triggered by a single genetic defect. Therefore, the discove...

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Literature Corpus work: 6106e442-e42a-5a79-84fb-56f24b990b27
DOI: 10.1101/2025.01.21.25320127

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