Article

An NF-κB/IRF1 axis programs cDC1s to drive anti-tumor immunity

2020-12-28

Abstract excerpt

Conventional type 1 dendritic cells (cDC1s) are critical for anti-tumor immunity. They acquire antigens from dying tumor cells and cross-present them to CD8 + T cells, promoting the expansion of tumor-specific cytotoxic T cells. However, the signaling pathways that govern the anti-tumor functions of cDC1s are poorly understood. We mapped the molecular pathways regulating intra-tumoral cDC1 maturation using single...

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Literature Corpus work: 536851fc-fc27-5160-9319-36d7ad3b1567
DOI: 10.1101/2020.12.28.424621

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