Article

PD-1 Mediated Regulation of Unique Activated CD8 <sup>+</sup> T Cells by NK Cells in the Submandibular Gland

2023-09-17

Abstract excerpt

<h4>Summary</h4> The increasing utilization of anti-PD-1 immune checkpoint blockade (ICB) has led to the emergence of immune-related adverse events (irAEs), including sicca syndrome. Interestingly, we found that the submandibular gland (SMG) of PD-1 deficient mice harbors a large population of CD8 + T cells, reminiscing ICB induced sicca. This phenotype was also observed in the SMG of both NK cell-depleted C57BL...

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Literature Corpus work: c995a986-81e7-5e67-a200-f1561e176266
DOI: 10.1101/2023.09.15.557930

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