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An <i>in vitro</i> assay of MCTS1-DENR-dependent re-initiation and ribosome profiling uncover the activity of MCTS2 and distinct function of eIF2D

2024-06-05

Abstract excerpt

Ribosomes scanning from the mRNA 5′ cap to the start codon may initiate at upstream open reading frames (uORFs), decreasing protein biosynthesis. Termination at a uORF can lead to re-initiation, where the 40S subunit resumes scanning and initiates another translation event downstream. In mammals, the noncanonical translation factors MCTS1-DENR participate in re-initiation at specific uORFs, but knowledge of other...

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Literature Corpus work
89fdbe1b-42f9-5f8c-9aeb-b15d71057f65
DOI
10.1101/2024.06.05.597545
Open publication

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An <i>in vitro</i> assay of MCTS1-DENR-dependent re-initiation and ribosome profiling uncover the activity of MCTS2 and distinct function of eIF2DDOI 10.1101/2024.06.05.597545
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