Article

DENR/MCTS1 knockdown modulates repeat-associated non-AUG translation

2021-08-28

Abstract excerpt

Repeat associated non-AUG (RAN) translation of mRNAs containing repeat-expansion mutations produces toxic peptides in neurons of patients suffering from neurodegenerative diseases. Recent findings indicate that RAN translation in diverse model systems is not inhibited by cellular stressors that impair global translation through phosphorylation of the alpha subunit of eIF2, the essential eukaryotic translation init...

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Literature Corpus work: a87566c9-1666-5abe-b2ae-b92cb2d138b9
DOI: 10.1101/2021.08.27.457993

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