Article

Human eIF2A has a minimal role in translation initiation and in uORF-mediated translational control in HeLa cells

2024-11-20

Abstract excerpt

<h4>SUMMARY</h4> Initiation of translation on eukaryotic mRNAs requires a 40S ribosome loaded with an initiator tRNA in order to scan for, and to identify, an initiation codon. Under most conditions, the initiator tRNA is recruited to the ribosome as part of a ternary complex composed of initiator tRNA, eIF2 and GTP. Although this function of recruiting the initiator tRNA was originally ascribed to another factor...

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Literature Corpus work: f79ebf6b-be22-53ca-9246-810692b5d98c
DOI: 10.1101/2024.11.20.624465

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Human eIF2A has a minimal role in translation initiation and in uORF-mediated translational control in HeLa cellsDOI 10.1101/2024.11.20.624465Read

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