Article
The eukaryotic initiation factor (eIF) 4G HEAT domain promotes translation re-initiation in yeast both dependent on and independent of eIF4A mRNA helicase.
The Journal of biological chemistry - 16 Jul 2010
Watanabe Ryosuke, Murai Marcelo Jun, Singh Chingakham Ranjit, Fox Stephanie, Ii Miki, Asano Katsura
Abstract excerpt
Translation re-initiation provides the molecular basis for translational control of mammalian ATF4 and yeast GCN4 mediated by short upstream open reading (uORFs) in response to eIF2 phosphorylation. eIF4G is the major adaptor subunit of eIF4F that binds the cap-binding subunit eIF4E and the mRNA helicase eIF4A and is also required for re-initiation in mammals. Here we show that the yeast eIF4G2 mutations altering...
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