Article

Direct analysis of ribosome targeting illuminates thousand-fold regulation of translation initiation

2020-04-30

Abstract excerpt

Translational control shapes the proteome in normal and pathophysiological conditions. Current high-throughput approaches reveal large differences in mRNA-specific translation activity but cannot identify the causative mRNA features. We developed direct analysis of ribosome targeting (DART) and used it to dissect regulatory elements within 5′ untranslated regions that confer thousand-fold differences in ribosome r...

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Literature Corpus work: 532c5e75-2996-5baf-aeae-6185182c57ac
DOI: 10.1101/2020.04.28.066068

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