Article
De Novo Mutations in DENR Disrupt Neuronal Development and Link Congenital Neurological Disorders to Faulty mRNA Translation Re-initiation.
Cell reports - 7 Jun 2016
Haas Matilda A, Ngo Linh, Li Shan Shan, Schleich Sibylle, Qu Zhengdong, Vanyai Hannah K, Cullen Hayley D, Cardona-Alberich Aida, Gladwyn-Ng Ivan E, Pagnamenta Alistair T, Taylor Jenny C, Stewart Helen, Kini Usha, Duncan Kent E, Teleman Aurelio A, Keays David A, Heng Julian I-T
Abstract excerpt
Disruptions to neuronal mRNA translation are hypothesized to underlie human neurodevelopmental syndromes. Notably, the mRNA translation re-initiation factor DENR is a regulator of eukaryotic translation and cell growth, but its mammalian functions are unknown. Here, we report that Denr influences the migration of murine cerebral cortical neurons in vivo with its binding partner Mcts1, whereas perturbations to...
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