Article

Reconstitution of <i>C9orf72</i> (GGGGCC) repeat-associated non-AUG translation with purified components

2023-05-29

Abstract excerpt

Nucleotide repeat expansion of GGGGCC (G 4 C 2 ) in the non-coding region of C9orf72 is the most common genetic cause underlying amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). Transcripts harboring this repeat expansion undergo the translation of dipeptide repeats via a non-canonical process known as repeat-associated non-AUG (RAN) translation. In order to ascertain the essential compone...

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Literature Corpus work: 2b73c962-4283-54e4-ac02-63a356b846df
DOI: 10.1101/2023.05.29.542719

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