Article

Brain Cell-based Genetic Subtyping and Drug Repositioning for Alzheimer Disease

2024-06-21

Abstract excerpt

Alzheimer’s Disease (AD) is characterized by its complex and heterogeneous etiology and gradual progression, leading to high drug failure rates in late-stage clinical trials. In order to better stratify individuals at risk for AD and discern potential therapeutic targets we employed a novel procedure utilizing cell-based co-regulated gene networks and polygenic risk scores (cbPRSs). After defining genetic subtypes...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 89dd1967-195a-5509-806d-8fb3f2e146a1
DOI: 10.1101/2024.06.21.24309255

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Brain Cell-based Genetic Subtyping and Drug Repositioning for Alzheimer DiseaseDOI 10.1101/2024.06.21.24309255Read

Network-based Translation of GWAS Findings to Pathobiology and Drug Repurposing for Alzheimer’s DiseaseSemantic proximity Read

Multi-Omics Analysis for Identifying Cell-Type-Specific Druggable Targets in Alzheimer’s DiseaseSemantic proximity Read

APOE*4 risk-modifying genes and drug targets in Alzheimer's disease through cell-type-specific genomic analyses.Semantic proximity Read

Multi-omics analysis for identifying cell-type-specific and bulk-level druggable targets in Alzheimer's disease.Semantic proximity Read

omicSynth: an Open Multi-omic Community Resource for Identifying Druggable Targets across Neurodegenerative DiseasesSemantic proximity Read

Identification of potential drug targets for Alzheimer's disease from genetic insights: A Mendelian randomization study.Semantic proximity Read

<i>APOE</i> *4 Risk-Modifying Genes and Drug Targets in Alzheimer’s Disease through Cell-Type Specific Genomic AnalysesSemantic proximity Read

Decoding the Genetic Comorbidity Network of Alzheimer's DiseaseSemantic proximity Read

Integrated Bioinformatics and Ensemble Learning Reveal Diagnostic Modeling and Drug Discovery in Alzheimer’s DiseaseSemantic proximity Read

Genetic and Multi-omic Risk Assessment of Alzheimer’s Disease Implicates Core Associated Biological DomainsSemantic proximity Read

Genetic and multi‐omic risk assessment of Alzheimer's disease implicates core associated biological domainsSemantic proximity Read

Genetic and Multi-omic Risk Assessment of Alzheimer’s Disease Implicates Core Associated Biological DomainsSemantic proximity Read