Article

omicSynth: an Open Multi-omic Community Resource for Identifying Druggable Targets across Neurodegenerative Diseases

2023-04-12

Abstract excerpt

<h4>Summary</h4> Treatments for neurodegenerative disorders remain rare, although recent FDA approvals, such as Lecanemab and Aducanumab for Alzheimer’s Disease, highlight the importance of the underlying biological mechanisms in driving discovery and creating disease modifying therapies. The global population is aging, driving an urgent need for therapeutics that stop disease progression and eliminate symptoms....

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 70e2d40f-92d0-556a-afea-1b0e1f1ee6a7
DOI: 10.1101/2023.04.06.23288266

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

omicSynth: an Open Multi-omic Community Resource for Identifying Druggable Targets across Neurodegenerative DiseasesDOI 10.1101/2023.04.06.23288266Read

Multicomponent Mendelian randomization and machine learning studies of potential drug targets for neurodegenerative diseasesSemantic proximity Read

AlzGPS: A Genome-wide Positioning Systems Platform to Catalyze Multi-omics for Alzheimer’s Therapeutic DiscoverySemantic proximity Read

Multi-Omics Analysis for Identifying Cell-Type-Specific Druggable Targets in Alzheimer’s DiseaseSemantic proximity Read

Network medicine informed multi-omics integration identifies drug targets and repurposable medicines for Amyotrophic Lateral SclerosisSemantic proximity Read

Combining cell type-specific genomic/epigenomic analyses and experimental validation identifies genetic drivers across three neurodegenerative diseasesSemantic proximity Read

Constructing Parkinson's disease progression- endotype molecular networks for drug repurposing: multi-omics evidence aggregation and large-scale real-world data validationSemantic proximity Read

AlzGPS: a genome-wide positioning systems platform to catalyze multi-omics for Alzheimer’s drug discoverySemantic proximity Read

Scrutinizing neurodegenerative diseases: decoding the complex genetic architectures through a multi-omics lens.Semantic proximity Read

Genetic and Multi-omic Risk Assessment of Alzheimer’s Disease Implicates Core Associated Biological DomainsSemantic proximity Read

Omics Data and Their Integrative Analysis to Support Stratified Medicine in Neurodegenerative DiseasesSemantic proximity Read

Network medicine informed multi-omics integration identifies drug targets and repurposable medicines for Amyotrophic Lateral SclerosisSemantic proximity Read

Genetic and multi‐omic risk assessment of Alzheimer's disease implicates core associated biological domainsSemantic proximity Read