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Article

APOE*4 risk-modifying genes and drug targets in Alzheimer's disease through cell-type-specific genomic analyses.

Alzheimer's & dementia : the journal of the Alzheimer's Association - 1 Jun 2026

Zeng Youjie, Cook Noah, Yang Chenyu, Sivasankaran Sathesh K, Fujita Masashi, Gardell Zachary A, Le Guen Yann, Shigemizu Daichi, Ozaki Kouichi, Morizono Takashi, Hara Norikazu, Miyashita Akinori, Ikeuchi Takeshi, Pottier Cyril, Cruchaga Carlos, Napolioni Valerio, Corces M Ryan, Menon Vilas, Greicius Michael D, Belloy Michael E

Abstract excerpt

INTRODUCTION: Genetics studies can identify drug targets that counteract the effects of the apolipoprotein E ε4 allele (APOE*4) on Alzheimer's disease (AD) but have remained limited in power and crucially did not assess genetic findings with regard to APOE*4's cell-type-specific impact on pathobiology. METHODS: We conducted a novel APOE*4-stratified genome-wide association study (GWAS) of AD (N = 447,669) and...

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PMID: 42328930
DOI: 10.1002/alz.71552
PMCID: PMC13285033

Genes

APOE

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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