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Article

Multi-omics analysis for identifying cell-type-specific and bulk-level druggable targets in Alzheimer's disease.

Journal of translational medicine - 13 Jul 2025

Liu Shiwei, Cho Minyoung, Huang Yen-Ning, Park Tamina, Chaudhuri Soumilee, Rosewood Thea J, Bice Paula J, Chung Dongjun, Bennett David A, Ertekin-Taner Nilüfer, Saykin Andrew J, Nho Kwangsik

Abstract excerpt

BACKGROUND: Analyzing disease-linked genetic variants via expression quantitative trait loci (eQTLs) helps identify potential disease-causing genes. Previous research prioritized genes by integrating Genome-Wide Association Study (GWAS) results with tissue-level eQTLs. Recent studies have explored brain cell type-specific eQTLs, but a systematic analysis across multiple Alzheimer's disease (AD) genome-wide...

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Identifiers

PMID: 40653482
DOI: 10.1186/s12967-025-06739-1
PMCID: PMC12257706

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PABPC1

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