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Multi-Omics Analysis for Identifying Cell-Type-Specific Druggable Targets in Alzheimer’s Disease

2025-01-09

Abstract excerpt

<h4>Background</h4> Analyzing disease-linked genetic variants via expression quantitative trait loci (eQTLs) is important for identifying potential disease-causing genes. Previous research prioritized genes by integrating Genome-Wide Association Study (GWAS) results with tissue- level eQTLs. Recent studies have explored brain cell type-specific eQTLs, but they lack a systematic analysis across various Alzheimer’s...

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Literature Corpus work
301b218b-9026-5b76-aa18-665cb17e1500
DOI
10.1101/2025.01.08.25320199
Open publication

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