Article

Network-based Translation of GWAS Findings to Pathobiology and Drug Repurposing for Alzheimer’s Disease

2020-01-18

Abstract excerpt

Genome-wide association studies (GWAS) have identified numerous susceptibility loci for Alzheimer’s disease (AD). However, utilizing GWAS to identify high-confidence AD risk genes (ARGs) that can guide development of new therapeutics for patients suffering from AD has heretofore not been successful. To address this critical problem in the field, we have developed a genotype-informed, network-based methodology that...

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Literature Corpus work: 92eeff6f-5497-5fc1-9fd9-1546f8347615
DOI: 10.1101/2020.01.15.20017160

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