Article
Diverse somatic genomic alterations in single neurons in chronic traumatic encephalopathy.
Science (New York, N.Y.) - 30 Oct 2025
Dong Guanlan, Ma Chanthia C, Mao Shulin, Brown Katherine Sun-Mi, Naik Samuel M, McDonough Gannon A, Wijethunga Samadhi P, Kim Junho, Kirkham Samantha L, Shao Diane D, Cherry Jonathan D, Uretsky Madeline, Spurlock Elizabeth, McKee Ann C, Huang August Yue, Miller Michael B, Lee Eunjung Alice, Walsh Christopher A
Abstract excerpt
Chronic traumatic encephalopathy (CTE) is a neurodegenerative disease linked to exposure to repetitive head impacts (RHI), yet little is known about its pathogenesis. Applying two single-cell whole-genome sequencing methods to hundreds of neurons from prefrontal cortex of 15 individuals with CTE and 4 with RHI without CTE, we revealed increased somatic single-nucleotide variants in CTE, exhibiting a pattern...
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