Article

Diverse somatic genomic alterations in single neurons in chronic traumatic encephalopathy

2025-03-04

Abstract excerpt

Chronic traumatic encephalopathy (CTE) is a neurodegenerative disease that is linked to exposure to repetitive head impacts (RHI), yet little is known about its pathogenesis. Applying two single-cell whole-genome sequencing methods to hundreds of neurons from prefrontal cortex of 15 individuals with CTE, and 4 with RHI without CTE, revealed increased somatic single-nucleotide variants in CTE, resembling a pattern...

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Literature Corpus work: b7fc3058-97e6-5f7b-82af-b768d64af33e
DOI: 10.1101/2025.03.03.641217

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