Article

Overexpression of diglucosyldiacylglycerol synthase leads to daptomycin resistance in <i>Bacillus subtilis</i>

2024-05-10

Abstract excerpt

The lipopeptide antibiotic daptomycin exhibits bactericidal activity against gram-positive bacteria by forming a complex with phosphatidylglycerol (PG) and lipid II in the cell membrane, causing membrane perforation. With the emergence of daptomycin-resistant bacteria, understanding the mechanism of bacterial resistance to daptomycin has gained great importance. In the present study, we found that overexpression o...

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Literature Corpus work: 896fa024-0efa-5bf1-a5eb-7053ae240e84
DOI: 10.1101/2024.05.10.593546

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