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Mechanisms of daptomycin resistance in Staphylococcus aureus: role of the cell membrane and cell wall

5 Dec 2012

Abstract excerpt

The bactericidal, cell membrane-targeting lipopeptide antibiotic daptomycin (DAP) is an important agent in treating invasive Staphylococcus aureus infections. However, there have been numerous recent reports of development of daptomycin resistance (DAP-R) during therapy with this agent. The mechanisms of DAP-R in S. aureus appear to be quite diverse. DAP-R strains often exhibit progressive accumulation of single...

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PMID: 23215859
DOI: 10.1111/j.1749-6632.2012.06819.x

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