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Article

Defective pgsA contributes to increased membrane fluidity and cell wall thickening in Staphylococcus aureus with high-level daptomycin resistance.

mSphere - 25 Jun 2024

Freeman Christian D, Hansen Tayte, Urbauer Ramona, Wilkinson Brian J, Singh Vineet K, Hines Kelly M

Abstract excerpt

Daptomycin is a membrane-targeting last-resort antimicrobial therapeutic for the treatment of infections caused by methicillin- and/or vancomycin-resistant Staphylococcus aureus. In the rare event of failed daptomycin therapy, the source of resistance is often attributable to mutations directly within the membrane phospholipid biosynthetic pathway of S. aureus or in the regulatory systems that control cell...

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Identifiers

PMID: 38752757
DOI: 10.1128/msphere.00115-24
PMCID: PMC11332330

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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