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Article

Genetic basis for in vivo daptomycin resistance in enterococci.

The New England journal of medicine - 8 Sept 2011

Arias Cesar A, Panesso Diana, McGrath Danielle M, Qin Xiang, Mojica Maria F, Miller Corwin, Diaz Lorena, Tran Truc T, Rincon Sandra, Barbu E Magda, Reyes Jinnethe, Roh Jung H, Lobos Elizabeth, Sodergren Erica, Pasqualini Renata, Arap Wadih, Quinn John P, Shamoo Yousif, Murray Barbara E, Weinstock George M

Abstract excerpt

BACKGROUND: Daptomycin is a lipopeptide with bactericidal activity that acts on the cell membrane of enterococci and is often used off-label to treat patients infected with vancomycin-resistant enterococci. However, the emergence of resistance to daptomycin during therapy threatens its usefulness. METHODS: We performed whole-genome sequencing and characterization of the cell envelope of a clinical pair of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 21899450
DOI: 10.1056/NEJMoa1011138
PMCID: PMC3205971

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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