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Article

Mechanism of High-Level Daptomycin Resistance in Corynebacterium striatum.

mSphere - 8 Aug 2018

Goldner Nicholas K, Bulow Christopher, Cho Kevin, Wallace Meghan, Hsu Fong-Fu, Patti Gary J, Burnham C A, Schlesinger Paul, Dantas Gautam

Abstract excerpt

Daptomycin, a last-line-of-defense antibiotic for treating Gram-positive infections, is experiencing clinical failure against important infectious agents, including Corynebacterium striatum The recent transition of daptomycin to generic status is projected to dramatically increase availability, use, and clinical failure. Here we confirm the genetic mechanism of high-level daptomycin resistance (HLDR; MIC =...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 30089649
DOI: 10.1128/mSphereDirect.00371-18
PMCID: PMC6083094

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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