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A liaR Deletion Restores Susceptibility to Daptomycin and Antimicrobial Peptides in Multidrug-Resistant Enterococcus faecalis

31 Oct 2014

Abstract excerpt

Daptomycin is a lipopeptide antibiotic that is used clinically against many gram-positive bacterial pathogens and is considered a key frontline bactericidal antibiotic to treat multidrug-resistant enterococci. Emergence of daptomycin resistance during therapy of serious enterococcal infections is a major clinical issue. In this work, we show that deletion of the gene encoding the response regulator, LiaR (a...

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PMID: 25362197
DOI: 10.1093/infdis/jiu602

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A liaR Deletion Restores Susceptibility to Daptomycin and Antimicrobial Peptides in Multidrug-Resistant Enterococcus faecalisPMID 25362197Read ↗

Deletion of liaR Reverses Daptomycin Resistance in Enterococcus faecium Independent of the Genetic BackgroundSemantic proximity Read ↗

Antimicrobial sensing coupled with cell membrane remodeling mediates antibiotic resistance and virulence in <i>Enterococcus faecalis</i>Semantic proximity Read ↗

LiaR‐independent pathways to daptomycin resistance in Enterococcus faecalis reveal a multilayer defense against cell envelope antibioticsSemantic proximity Read ↗

Molecular basis of cell membrane adaptation in daptomycin-resistant Enterococcus faecalisSemantic proximity Read ↗

Exogenous Fatty Acids Protect Enterococcus faecalis from Daptomycin-Induced Membrane Stress Independently of the Response Regulator LiaRSemantic proximity Read ↗

Daptomycin resistance in <i>Enterococcus faecium</i> can be delayed by disruption of the LiaFSR stress response pathwaySemantic proximity Read ↗

Mechanisms of drug resistance: daptomycin resistance.Semantic proximity Read ↗

Genetic basis for in vivo daptomycin resistance in enterococci.Semantic proximity Read ↗

Daptomycin resistant Enterococcus faecalis has a mutation in liaX, which encodes a surface protein that inhibits the LiaFSR systems and cell membrane remodeling.Semantic proximity Read ↗

An Adaptive Mutation in Enterococcus faecium LiaR Associated with Antimicrobial Peptide Resistance Mimics Phosphorylation and Stabilizes LiaR in an Activated State.Semantic proximity Read ↗

Environment Shapes the Accessible Daptomycin Resistance Mechanisms in <i>Enterococcus faecium</i>Semantic proximity Read ↗

Novel regulatory logic in the antibiotic resistance response of <i>Enterococcus faecalis</i> against cell envelope targeting antibioticsSemantic proximity Read ↗

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