Article
Differential daptomycin resistance development in Staphylococcus aureus strains with active and mutated gra regulatory systems.
International journal of medical microbiology : IJMM - 1 Apr 2018
Müller Anna, Grein Fabian, Otto Andreas, Gries Kathrin, Orlov Dmitriy, Zarubaev Vladimir, Girard Myriam, Sher Xinwei, Shamova Olga, Roemer Terry, François Patrice, Becher Dörte, Schneider Tanja, Sahl Hans-Georg
Abstract excerpt
The first-in-class lipopeptide antibiotic daptomycin (DAP) is highly active against Gram-positive pathogens including ß-lactam and glycopeptide resistant strains. Its molecular mode of action remains enigmatic, since a defined target has not been identified so far and multiple effects, primarily on the cell envelope have been observed. Reduced DAP susceptibility has been described in S. aureus and enterococci...
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