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Article

Antimicrobial sensing coupled with cell membrane remodeling mediates antibiotic resistance and virulence in <i>Enterococcus faecalis</i>

9 Dec 2019

Abstract excerpt

Bacteria have developed several evolutionary strategies to protect their cell membranes (CMs) from the attack of antibiotics and antimicrobial peptides (AMPs) produced by the innate immune system, including remodeling of phospholipid content and localization. Multidrug-resistant Enterococcus faecalis, an opportunistic human pathogen, evolves resistance to the lipopeptide daptomycin and AMPs by diverting the...

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Share to Antibiotic Resistance in Bacteria
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 31818937
DOI: 10.1073/pnas.1916037116

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Antimicrobial sensing coupled with cell membrane remodeling mediates antibiotic resistance and virulence in <i>Enterococcus faecalis</i>PMID 31818937Read ↗

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Novel regulatory logic in the antibiotic resistance response of <i>Enterococcus faecalis</i> against cell envelope targeting antibioticsSemantic proximity Read ↗

LiaX is a surrogate marker for cell envelope stress and daptomycin non-susceptibility in Enterococcus faeciumSemantic proximity Read ↗

Daptomycin resistant Enterococcus faecalis has a mutation in liaX, which encodes a surface protein that inhibits the LiaFSR systems and cell membrane remodeling.Semantic proximity Read ↗

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Deletion of liaR Reverses Daptomycin Resistance in Enterococcus faecium Independent of the Genetic BackgroundSemantic proximity Read ↗

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