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Article

LiaR‐independent pathways to daptomycin resistance in Enterococcus faecalis reveal a multilayer defense against cell envelope antibiotics

24 Dec 2018

Abstract excerpt

The lipopeptide antibiotic daptomycin (DAP) is a key drug against serious enterococcal infections, but the emergence of resistance in the clinical setting is a major concern. The LiaFSR system plays a prominent role in the development of DAP resistance (DAP-R) in enterococci, and blocking this stress response system has been proposed as a novel therapeutic strategy. In this work, we identify LiaR-independent...

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PMID: 30582877
DOI: 10.1111/mmi.14193

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LiaR‐independent pathways to daptomycin resistance in Enterococcus faecalis reveal a multilayer defense against cell envelope antibioticsPMID 30582877Read ↗

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Antimicrobial sensing coupled with cell membrane remodeling mediates antibiotic resistance and virulence in <i>Enterococcus faecalis</i>Semantic proximity Read ↗

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Deletion of liaR Reverses Daptomycin Resistance in Enterococcus faecium Independent of the Genetic BackgroundSemantic proximity Read ↗

Daptomycin resistant Enterococcus faecalis has a mutation in liaX, which encodes a surface protein that inhibits the LiaFSR systems and cell membrane remodeling.Semantic proximity Read ↗

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LiaX is a surrogate marker for cell envelope stress and daptomycin non-susceptibility in Enterococcus faeciumSemantic proximity Read ↗

Genetic basis for in vivo daptomycin resistance in enterococci.Semantic proximity Read ↗

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